Researcher of the Month
Decemer 2024
Divleen Singh
Major: Biology (Interdisciplinary specialization); WISE-Scholars for Medicine
Research Mentors: Dr. Miriam Rafailovich (Chemical Engineering & Materials Science), Dr. Marcia Simon (Oral Biology & Pathology), and Dr. Gurtej Singh (Plastic & Reconstructive Surgery)
Divleen Kaur Singh is a Biology major (Interdisciplinary specialization) in the WISE - Scholars for Medicine dual degree (B.S./M.D.) program, on track to graduate summa cum laude (December 2024). Since Fall 2023, Divleen has been a valued, productive member of the Stem Cell Engineering Vertically Integrated Project (VIP) Team where she works on tissue engineering and the design of pre-vascularized skin constructs for eventual usage in wound healing and skin regeneration. Within the collaborative research environment fostered by Dr. Miriam Rafailovich (Chemical Engineering & Materials Science), Dr. Marcia Simon (Oral Biology & Pathology), and Dr. Gurtej Singh (Plastic & Reconstructive Surgery), Divleen has excelled. After a summer of full-time research funded by the 2024 URECA Summer program, Divleen had the opportunity to present “Exploring the In Vivo Integration and Functionality of Engineered Vascularized Skin Constructs within Murine Models” at the 2024 Plastic Surgery The Meeting conference in San Diego, California this past September and was recognized with a “Best Abstract Presentation” award in the Research and Technology (6) session. She also received a URECA mini-grant to support her conference presentation. Earlier this spring, Divleen presented a poster titled “Bandaging Your Super Active Mice” at the 2024 Stony Brook VIP-URECA Celebration Showcase. Over the summer, Divleen has also helped mentor high school students in the Garcia Summer Research program. She plans to use the research experiences from the VIP team for her WISE thesis. She is also currently helping with and learning about a separate Department of Surgery research project with Dr. Gurtej Singh and Dr. Nicos Labropoulos on the development of an arterial and venous thrombosis murine model to improve clinical outcomes.
Divleen got off to a great start at Stony Brook in her freshman year by joining the iGEM/International Genetically Engineered Machinesteam mentored by Dr. Peter Gergen (Director of Undergraduate Biology program). Over summer 2022, she worked as a wet lab team leader on a synthetic biology project to investigate Protein S deficiency in humans, a project for which the iGEM team earned a Gold medal in the 2022 iGEM Jamboree competition in Paris. For the last two and a half years, Divleen has also been active in the Department of Emergency Medicine’s Academic Associate internship program. Divleen gained proficiency in using Electronic Medical Records for enrollment in clinical studies and was trained to perform neurocognitive testing and write patient case reports. In addition, Divleen served on the Student Leadership Council for WISE, helped organized workshops for Scholars for Medicine, was a member and collaborator with the Stony Brook Hispanic Heart Program, and was on the E-board of the University Red Cross Club. She has also done physician shadowing at Stony Brook in the OR and Emergency Department and has volunteered as an EMT in Somerset, NJ over the last 4 years.
Through research, the process of making connections, collaborating with others, and contributing to a team have been invaluable for her undergraduate education. Divleen reflects: “I really enjoy how so many people work together on this research, and everybody has their own specialty or something to contribute. I think that is what makes our team so successful because everybody plays an unique role, and when everything comes together, it works very beautifully. I think it's a great process.”
Divleen’s hobbies include cooking, reading, baking, and gardening. Divleen will be attending medical school at the Stony Brook Renaissance School of Medicine in 2025 and is interested in pursuing a career in plastic and reconstructive surgery. She is a graduate of Rutgers Preparatory School, New Jersey and had a formative research experience during high school as a member of the Waksman Student Scholars Research Program. Below are excerpts of her interview with Karen Kernan, URECA Director.
The Interview:
Karen: Tell me how you got started in research at Stony Brook, and about your research journey on campus.
Divleen: My research at Stony Brook started out with iGEM. I applied during my freshman year,
and it was a great experience because I got to work with mentors like Dr. Gergen.
We worked on an amazing project that we then took to the international level at the
Conference.
I also applied to an internship called Academic Associates that takes place in the
Emergency Department at the hospital. As interns, we screen for patients in the Emergency
Department for enrollment in different clinical studies. This is the start of my third
year in the program, and I absolutely love it. I think it's such a great way to get
involved in learning how clinical research in medicine works. You are also able to
develop exceptional communication skills when you learn to explain studies to patients
who have never heard about them before.
I have always known that I wanted to be more involved in research within a specialty
that was of great interest to me in medicine and to get a head start before I started
medical school. I’ve become very interested in plastic surgery -- an area that can
change the quality of patients’ lives. Plastic surgery is unique in that you can individualize
surgical treatment for every patient. Traumatic injuries can greatly affect patients’
daily living, and plastic surgeons can repair things like facial trauma, arm trauma,
and burn injuries to help patients. Last year, I reached out to Grace Agnetti, the
Assistant Dean for Admissions at Stony Brook Medicine and someone who is greatly involved
with the Scholars for Medicine program. She connected me to plastic surgeons who connected
me to Dr. Gurtej Singh who works very closely with Dr. Miriam Rafailovich and Dr.
Marcia Simon through the VIP Stem Cell Engineering team. It was through VIP that I
found such a great match to my research interests.
Our lab’s goal is to develop pre-vascularized tissue engineered skin grafts. We have had very successful results with the grafts in murine models. We are currently interested in decellularizing the grafts so that they can be eventually tested for use in humans. Thanks to URECA, I was able to be on campus and spend every week with the group, and I ended up traveling to a conference in September to present the work, showing the successful results of our grafts at the Plastic Surgery Meeting Conference in San Diego, CA. I presented in front of medical students, surgical residents, and accomplished surgeons. I recently received a “Best Abstract Presentation” award from the session that I presented in!
Congratulations! How would you say that being involved in research has complemented what you learn in classes?
Classes at Stony Brook move very fast, especially in laboratory classes. Research allows you to apply information you've learned in those labs and classes, learn it more deeply, and put it towards something like major projects that are the future of science. I learned how to make agarose gels in SBU lab classes, so when I did iGEM, I was able to apply those experiences and make gels almost every day for a month. The research that I'm involved in currently deals with cells and immune reactions. So much of what has prepared me for this work came from a course called Cancer Biology taught by Dr. Erster. I've mentioned what she had taught about immune pathways and angiogenesis in VIP meetings. Through research, I have understood the value of what I learned earlier in my classes.
You've mentioned many different involvements on campus. I wanted to give you the opportunity to comment on WISE and the Scholars for Medicine programs. How have these programs helped you as an undergraduate?
WISE was one of the best ways for me to get involved in and acclimated to campus.
WISE is a great group of women in STEM. I made many friends through WISE, and many
of the classes that I took prepared me for life beyond graduation, networking, and
applying to jobs and internships. My advisors, Doreen Aveni and Jacquelyn Gatta, have
helped me greatly, especially when it came to wanting to graduate early.
Scholars for Medicine has also been a great program. You're able to connect with so
many professionals. Grace Agnetti helped me to network with professionals at the hospital.
Through the program, students have been able to work with Dr. David Cohen, the Dean
of Student Affairs, to take part in clinical workshops and gain advice. Knowing that
you're going to be a part of the medical school motivates you to get to know the physicians
and patients and to make connections. As a SFM student, I know that getting involved
with the medical school early on will let me establish connections that will continue
beyond my undergraduate years.
What would you say is your favorite part of the research experience in general?
My favorite part is being able to share the work that we do with others. When you're able to share the impact of your research with others and help them understand what you do, you can connect with them and explain the potential of your research. Sometimes, you’re able to spark interest in students and motivate them. I’ve experienced this with the students from my high school in NJ. I also enjoy talking to and connecting with professionals, physicians, or researchers who have much more experience than I do. At the conference I recently attended, I was able to learn many things from residents and medical students. Research has been a great way to make connections.
If you were talking to other undergraduates, what advice would you give them about undergraduate research?
Don’t hesitate to reach out to a professional you are interested in working with. It is likely that you will get a response from them, and you might end up working with them and taking part in things that you never thought were possible.
I never thought I would be going to a conference that usually only medical students and physicians attend. I was one of the only undergraduates present. You never know what might come your way. So if you're interested in something, go for it. Stony Brook has so much to offer in terms of research, and I think there is something out there for everyone.
Can you talk a little bit about your mentors? How have they helped you in terms of your career path?
Dr. Miriam Rafailovich has been very influential in my path. Whenever I have questions, she always answers them. She is always eager to invite students to come and witness what goes on in the lab. She has introduced me to many individuals. Dr. Gurtej Singh has also been a great mentor. He gave me the opportunity to present at the conference in California, and I was able to win an award. Dr. Marcia Simon has so much experience with cell research, and learning from her is a great privilege. All of my mentors have been very influential.
Is there anything else you want to add about undergraduate research?
I believe that getting involved with research as early as possible allows one to build long-term connections and work on projects for a long time. All the work that you put in will be helpful in your future path. Thanks to my mentors and to their belief in me, I’ve been given great opportunities to grow and show my potential.