Daniel Klein, Ph.D.
State University of New York at Buffalo (1983) Distinguished Professor, Clinical Psychology
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Contact: daniel.klein@stonybrook.edu |
Dr. Daniel Klein plans to admit a new graduate student pending approval of funding.
Research Interests:
Dr. Klein is interested in developmental psychopathology and adult psychopathology, particularly mood disorders in children, adolescents, and adults. His research explores the intergenerational transmission of depression; the roles of temperament and emotional reactivity, and early adversity in the development and course of mood disorders; the long-term course and continuity of mood disorders; the classification of mood disorders; comorbidity between depression and other disorders; and the psychotherapeutic and psychopharmacological treatment of depressive disorders.
Current Research:
Dr. Klein is currently directing a longitudinal study of the role of early temperament and emotional style in the development of later mood and anxiety disorders in a large community sample of children (the Stony Brook Temperament Study). The children were assessed at ages 3, 6, 9, 12, 15, and 18 and are currently being assessed again at age 21. The study uses multiple measurement strategies to assess potential risk, protective, mediating, and moderating factors in multiple domains, including child emotional reactivity and regulation, psychopathology, psychophysiological and behavioral measures of processing of emotional information; ecological momentary assessment of mood and social interactions; polygenic risk scores, stress and pubertal hormones, parenting, life stress, and parental personality and psychopathology.
Together with Dr. Roman Kotov (Psychiatry), Dr. Klein is also directing a longitudinal study of a large sample of early adolescent girls who have been followed on six occasions to age 20 (the Adolescent Development of Emotions and Personality Traits study) and are currently being assessed again at age 25. This project also seeks to identify antecedents of, and pathways to, depressive disorders, and uses many of the same measures as the Stony Brook Temperament Study. In addition, the current wave of assessments aims to identify predictors of the course of depression and to parse the heterogeneity of depression by distinguishing individuals with brief and infrequent episodes of depression from those with very frequent or persistent depression.
Selected Awards:
Distinguished Scientist Award, Society for a Science of Clinical Psychology (Section III, Division 12, American Psychological Association)
Joseph Zubin Award for Lifetime Contributions in Psychopathology, Society for Research in Psychopathology
Distinguished Scientific Contributions to Clinical Psychology, Society of Clinical Psychology (Division 12, American Psychological Association)
Lawrence H. Cohen Outstanding Mentor Award, Society for a Science of Clinical Psychology (Section III, Division 12, American Psychological Association)
John Neale Sustained Mentorship Award, Society for Research in Psychopathology
Dean’s Award for Excellence in Graduate Mentoring by a Faculty Member, Stony Brook University
Selected Articles since 2021:
2021
Kessel, E.M., Frost, A, Goldstein, B.L., Black, S.R., Dougherty, L.R., Carlson, G.A., & Klein, D.N. (2021). Developmental pathways from preschool irritability to multifinality in early adolescence: the role of diurnal cortisol. Psychological Medicine, 51 761-769.
Klein, D.N., Dougherty, L.R., Kessel, E.M., Silver, J., Carlson, G.A. (2021). A transdiagnostic perspective on youth irritability. Current Directions in Psychological Science, 30, 437-443.
Michelini, G., Perlman, G., Tian, Y., Mackin, D. M., Nelson, B. D., Klein, D. N., & Kotov, R. (2021). Multiple domains of risk factors for first onset of depression in adolescent girls. Journal of Affective Disorders, 283, 20-29.
Olino, T., Michelini, G., Mennies, R.J., Kotov, R., & Klein, D.N. (2021). Does maternal psychopathology bias reports of offspring symptoms? A study using moderated non-linear factor analysis. Journal of Child Psychology and Psychiatry, 62, 1195-1201.
Silver, J., Carlson, G.A., Olino, T.M., Perlman, G., Kotov, R., & Klein, D.N. (2021). Differential outcomes of tonic and phasic irritability in adolescent girls. Journal of Child Psychology and Psychiatry, 62, 1220-1227.
Wojcieszak, Z.K., Mennies, R.J., Klein, D.N., Seeley, J.R., & Olino, T.M. (2021). Latent class analysis of adolescent psychosocial functioning and course of major depression. Research on Child and Adolescent Psychopathology, 49, 963–973.
2022
Hawes, M.T., Szenczy, A.K., Klein, D.N., Hajcak, G., & Nelson, B.D. (2022). Increases in depression and anxiety symptoms in adolescents and young adults during the COVID-19 pandemic. Psychological Medicine, 52, 3222-3230.
Hyland, S., Mackin, D.M., Goldstein, B.L., Finsaas, M.C., & Klein, D.N. (2022). Agreement, stability, and validity of parent- and self-reported youth anxiety symptoms from childhood to adolescence. Research on Child and Adolescent Psychopathology, 50, 1445-1455.
Mackin, D. M., Finsaas, M. C., Nelson, B. D., Perlman, G., Kotov, R., & Klein, D. N. (2022). Intergenerational transmission of depressive and anxiety disorders: Mediation via youth personality. Journal of Psychopathology and Clinical Science, 131, 467-478.
Olino, T.M., Finsaas, M.C., Dyson, M.W., Carlson, G.A., & Klein, D.N. (2022). A multi-method, multi-informant study of early childhood temperament and depression and anxiety symptoms in adolescence. Journal of Psychopathology and Clinical Science,131, 741-753.
Silver, J., Olino, T.M., Carlson, G.A., Dougherty, L.R., Bufferd, S.J., & Klein, D.N. (2022). Depression in early childhood: Clinical and psychosocial outcomes in late childhood and adolescence. Journal of Child Psychology and Psychiatry, 63, 984-991.
Sorcher, L.K., Goldstein, B.L., Finsaas, M.C., Carlson, G.A., Klein, D.N., & Dougherty, L.R. (2022). Preschool irritability predicts adolescent psychopathology and functional impairment: A 12-year prospective study. Journal of the American Academy of Child and Adolescent Psychiatry, 61, 554-564.
2023
Beatty, C. C., Ferry, R. A., Eaton, N. R., Klein, D. N., & Nelson, B. D. (2023). Neurobiological sensitivity to unpredictable threat and familial risk for the internalizing and externalizing spectra in adolescents. Psychological Medicine, 53(12), 5395-5404.
Finsaas, M.C., & Klein, D.N. (2023). Is adult separation anxiety associated with offspring risk for psychiatric problems? Psychological Medicine,53 (7), 3168-3177.
Harrison, T. J., Docherty, A. R., Finsaas, M. C., Kotov, R., Shabulin, A., Waszczuk, M. A., Katz, B. A, Davila, J. & Klein, D.N. (2023). Examining the relationship between genetic risk for depression and youth episodic stress exposure. Journal of Affective Disorders, 340, 649-657.
Hawes, M. T., Schwartz, H. A., Son, Y., & Klein, D. N. (2023). Predicting adolescent depression and anxiety from multi-wave longitudinal data using machine learning. Psychological Medicine, 53, 6205-6211.
Klein, D. N., Perlman, G., Feltman, S. M., & Kotov, R. (2023). Preonset predictors of chronic–intermittent depression from early adolescence to early adulthood. Journal of Psychopathology and Clinical Science, 132, 694–703.
Mackin, D.M., Goldstein, B.L., Mumper, E., Kujawa, A.J., Kessel, E., Olino, T.M., Nelson, B.D., Hajcak, G., & Klein, D.N. (2023). Longitudinal associations between reward processing and depression across adolescence. Journal of the American Academy of Child and Adolescent Psychiatry, 62 (7), 816-828.
Mu, W., Li, K., Tian, Y., Perlman, G., Michelini, G., Watson, D., Ormel, H., Klein, D.N., & Kotov, R. (2023). Dynamic risk for first onset of depressive disorders in adolescence: Does change matter? Psychological Medicine, 53, 2352-2360.
Silver, J., Bufferd, S.J., Dougherty, L.R., Goldstein, B.L., Carlson, G.A., Klein, D.N. (2023). Tonic and phasic irritability in 6-year old children: Differential correlates and outcomes. Journal of Child Psychology and Psychiatry, 64, 234-243.
2024
Beatty, C. C., Gair, K., Anatala, J., Klein, D.N. Hajcak, G., & Nelson, B.D. (2024). Neural response to monetary and social rewards and familial risk for psychopathology in adolescent females. Psychological Medicine, 54, 1768-1778.
DeGroot, H., Silver, J., Klein, D.N., & Carlson, G.A. (2024). Parent and teacher ratings of tonic and phasic irritability in a clinical sample. Research on Child and Adolescent Psychopathology, 52, 891-903.
Klein, D. N. (2024). Assessment of depression in adults and youth. Assessment, 31(1), 110-125.
Mu. W., Huang, C., Yao, N., Mao, J., Perlman, G., Watson, D., Klein, D.N., & Kotov, R. (2024). Developmental pathway for first onset of depressive disorders: From adolescence to emerging adulthood. Psychological Medicine, 54, 753-762.
Silver, J., Hawes, M.T., Dougherty, L.R., Bufferd, S.J., Kessel, E.M., Olino, T.M., Carlson, G.A., & Klein, D.N. (2024). Irritability and temperament: Concurrent and prospective relationships in childhood and adolescence. Journal of Clinical Child and Adolescent Psychology, 53, 156-168.
Silver, J., Sorcher, L., Carslon, G.A., Dougherty, L.R., & Klein, D.N. (2024). Irritability across adolescence: Examining longitudinal trajectory, stability, and associations with psychopathology and functioning at age 18. Journal of Affective Disorders, 354, 611-618.
In Press
Calentino, A.E., Yelimineti, R., Harrison, T.J., Jayakumar, S., Lawhead, C., & Klein, D.N. (in press). Persistent Depressive Disorder. In D.G. Friedman-Wheeler & A.E. Wenzel (Eds.), The SAGE Encyclopedia of Mood and Anxiety Disorders.
Chad-Friedman, S., Chad-Friedman, E., Lemay, E., Olino, T. M., Klein, D. N., & Dougherty, L. R. (in press). Within-person pathways among maternal depressive symptoms and offspring internalizing problems from early childhood through adolescence. Development and Psychopathology.
Grieshaber, A., Silver, J., Bufferd, S.J., Dougherty, L.R., Carlson G.A., & Klein, D.N. (in press). Early childhood anxiety disorders: Continuity and predictors in adolescence. European Child and Adolescent Psychiatry.
Hawes, M.T., & Klein, D.N. (in press). Emotion dynamics in current and remitted depression: An ecological momentary assessment study. Psychological Medicine.
Klein, D.N. (in press). Diagnosis and classification of depressive disorders. In Pettit, J.W., and Olino, T.M. (Eds.), APA Handbook of Depression, Washington, DC: American Psychological Association Press.
Perlman, G., Moeller, S., Kotov, R., Klein, D., Weinstein, J., Horga, G., & Abi Dargham, A. (in press). Neuromelanin-sensitive MRI signal is associated with lifetime substance use in young adults. American Journal of Psychiatry.
Silver, J., Hawes, M., Carlson, G., & Klein, D.N. (in press). Irritability: Concurrent and predictive associations with real-time affect dynamics, social interactions, and daily substance use in older adolescents. European Child and Adolescent Psychiatry.