• July 1963 - July 1967: Roscoe Rouse (director)
• July 1, 1967 - July 1, 1972: Ruben Weltsch (director)
• July 1972 - February 1974: Joseph Gantner (acting director)
• March 1, 1974 - July 16, 1997: John Brewster Smith (dean and director)
• August 1, 1996 - December 18, 1999: Joseph J. Branin (dean and director)
• December 20, 1999 - August 1, 2000: Charles W. Simpson (interim dean and director)
• August 1, 2000 - November 1, 2010: E. Christian Filstrup (dean and director)
• December 2010 - January 27, 2013: Andrew White (interim dean and director)
• January 28, 2013 - October 1, 2013: Daniel Kinney  (interim dean and director)
• October 1, 2013 - July 31, 2018: Constantia Constantinou (dean)
• August 1, 2018 - September 14, 2022: Shafeek Fazal (interim dean)
• September 15, 2022 - Karim Boughida (dean)

East Campus (Health Sciences Library)

• 1969 - 1973: Emil F. Frey (director)
• 1973: Mary Winkels (acting director)
• 1973 - 1979: Mary Winkels (director)
• 1979 - 1994: Ruth Marcolina (director)
• 1994 - 2008: Spencer Marsh (director)
• 2008 - 2009: Moisés Eisenberg (interim director)
• 2009: Andrew White (director)
  
  *Note: after 2009, the West Campus and East Campus libraries merged as the University Libraries.*